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Chronic knee pain limits physical activity, which promotes weight gain and worsens metabolic control, which drives further systemic inflammation, which accelerates joint damage, which increases pain further

Alterations in the hypothalamic paraventricular nucleus and its oxytocin neurons (putative satiety cells) in Prader-Willi syndrome: a study of five cases

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Similarly, respiratory symptoms such as cough, shortness of breath, or chest pain warrant assessment, as these are not attributable to the medication

potential differences in subgroup responses (e.g., with insulin resistance or obesity)