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However, this outcome is not inevitable

But insulin dose reduction needs to be done carefully and gradually, with close CGM monitoring, to avoid either hypoglycemia (from too much insulin relative to your new needs) or hyperglycemia (from reducing too aggressively)

Tirzepatide, a dual GIP and GLP-1 receptor agonist, helps regulate appetite and blood sugar by slowing gastric emptyingthe rate at which food moves from your stomach into your small intestine

Like GLP-1, its also released from your intestines when you eat
Anxiety about whether the new medication will work, frustration during retitration periods when appetite returns, and the cognitive load of tracking two different dosing protocols all take a psychological toll

Based on self-reported data by 645 patients, over the period of Jan 2024 to Apr 2025, patients who were prescribed GLP-1 medication experienced on average weight loss of 9.6 pounds in the first 30 days
