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Several ongoing clinical trials are investigating incretin-based therapies for alcohol use disorder, tobacco use disorder, and opioid use disorder

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In laboratory studies, GLP-1 RAs decrease de novo lipogenesis by down-regulating SREBP-1c and up-regulating AMPK, enhance -oxidation through PPAR- activation, and reduce oxidative stress through cAMP-PKA-mediated pathways [21, 24]

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