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However, it is not a required side effect

Trulicity (dulaglutide), has held a steady and growing share of the market in GLP-1s for T2D ( Figure 3 )

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Additionally, liraglutide, orforglipron, semaglutide, and tirzepatide were associated with increased vomiting risk, while cagrilinitide and exenatide showed no significant increase

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The two scientists overcame the problem by engineering fatty acids that bound more strongly to albumin so that it would stick longer to GLP which would make it remain active for longer in the body