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Briefly, snap-frozen liver samples were weighed and homogenized in chloroform:methanol (2:1) solution, followed by the addition of saline and centrifugation at 10,000 rpm to achieve phase separation

The integrated crosstalk among these pathways enhances cellular repair, energy homeostasis, and resilience, positioning GLP-1 RAs as central modulators of cellular homeostasis and linking molecular repair programs to translational gains in healthspan

Clinical outcomes such as cirrhosis progression, liver transplant, and all-cause mortality are recognized as solid endpoints for evaluating drug efficacy in MASLD

The US contributed the majority of the regions revenue, accounting for 95.2% of the weight-loss medication segment