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Childhood obesity rates have skyrocketed over 300% since the 1970s, now affecting 21% of children

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Diabetes leads to a significantly accelerated incidence of various related macrovascular complications, including peripheral vascular disease and cardiovascular disease (the most common cause of mortality in diabetes), as well as microvascular complications such as kidney disease and retinopathy

This approach highlights how nutritional substrates and metabolic cofactors may influence physiological resilience during sustained pharmacological weight reduction