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Regulatory agencies, including the European Medicines Agency and the World Health Organization, have issued warnings regarding NAION as a potential risk associated with semaglutide medications

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The STEP 4 extension (Rubino et al

This peptide has been implicated in modulating neuronal cell differentiation, neurite outgrowth, and performing neuroprotective functions through the activation of GLP-1 receptors (GLP-1Rs), class B sub-group G protein-coupled receptors [2, 6]

Practical progress depends on structured experiments and consistent measurement

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