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2019;9(11):e031431

47 In addition, despite high leptin production in response to overeating, leptin responsiveness becomes blunted in those with obesity and insulin resistance, such that high circulating leptin levels lose their impact on appetite and metabolism, resulting in a state described as leptin resistance

Various factors can affect these nerves, such as: A hair touching the eardrum Sore throat Tumors, goiters, or cysts in the neck Central nervous system disorders (e.g., encephalitis or meningitis) Metabolic disorders (e.g., diabetes or kidney failure) Certain medications (e.g., steroids or tranquilizers) Medical procedures requiring anesthesia If your hiccups last for more than 48 hours, are severe enough to interfere with daily activities like eating, breathing, or sleeping, or cause significant distress, it's essential to consult your doctor

Lin, J, Wang, H, Weng, H, Kao, P 1998

However, the experience can be different for each woman

No other significant changes in cardiometabolic risk factors were observed