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10.1371/journal.pone.0119034 124 RosenstockJ.FriasJ.JastreboffA

Bupropion, an atypical antidepressant, and a dopamine/norepinephrine reuptake inhibitor, is believed to promote weight loss through its stimulatory effect on pro-opiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus

These effects are possibly mediated through mechanisms that include, but are not limited to, improved glycemic control, reduced hepatic lipid production, enhanced fatty acid oxidation, and upregulated LDL receptor activity [52], offering a multifaceted therapeutic strategy for both diabetes and its associated metabolic disturbances

This examination documents any existing diabetic retinopathy, macular changes, optic nerve appearance, and overall retinal health

In the intestine, DPP-4 is highly expressed in the enterocyte brush border and in endothelial cells [191]

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