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The FDA has approved specific combinations (e.g., linagliptin + dulaglutide) for this purpose, reinforcing clinical acceptance
The SUMMIT trial below evaluated the effects of tirzepatide in obese patients with HFpEF
2022;1(6) doi: 10.1056/evidoa2200014
Vulnerable populations such as frail patients, pregnant women, adolescents and the elderly may be more susceptible to adverse effects like muscle loss or nutritional deficits
That was a type 2 diabetes drug
The incretin hormones GIP and GLP-1 are important substrates for DPP-4 action, while increased DPP-4 activity is associated with lower levels of GIP and GLP-1 [3]
