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This fatigue is often connected to other factors such as gastrointestinal side effects, dehydration, or changes in blood sugar as the body adapts to the medication
After overnight fasting, animals received PBS or test compounds (Semaglutide, Tirzepatide, or Retatrutide) in the morning, and food was provided 15 minutes post-dosing
Studies suggest these effects stem from weight loss, improved insulin sensitivity, and direct actions on metabolic pathways that regulate lipid production
The medications are mostly used for blood sugar management in people with type 2 diabetes or weight loss, Shah says
