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Treatment with tirzepatide in adults with pre-diabetes and obesity or overweight resulted in sustained weight loss, and nearly 99% remained diabetes-free at 176 weeks | Eli Lilly and Company

Discussion Thyroiditis refers to a group of inflammatory thyroid disorders that often present with a biphasic clinical course, beginning with transient thyrotoxicosis due to the release of preformed thyroid hormones, followed by a hypothyroid phase as hormone stores are depleted [4]
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Combined oral contraceptive use and obesity in women with polycystic ovary syndrome

Significant weight reduction may lower TSH in patients with obesity-related TSH elevation

A previous CB1 receptor blocker, Rimonabant, was approved in Europe in 2006 but was discontinued in 2008 owing to serious psychiatric side effects
