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In people with established T2DM, a 12-month trial of naltrexone/bupropion demonstrated a reduction in HbA 1c of 0.6% in participants who achieved a 5% body weight loss in the first 16 weeks, with a 9% body weight loss at 12 months

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[] Additional neuroprotective actions include promoting neuronal growth factordriven neuronal differentiation and repair, preserving cholinergic function through maintenance of acetylcholine synthesis, and stabilizing calcium responses to prevent glutamate-induced excitotoxicity