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Conversely, Glp1r knockout mice consumed greater quantities of nicotine than wild-type mice

The clinical relevance of these findings is underscored by the safety profile of GLP-1 agonists in long-term use and their established efficacy in reducing cardiovascular events

Growth Beyond Diabetes Into Obesity Management While GLP-1s were originally developed for diabetes treatment, a significant portion of their growth is now driven by their effectiveness in obesity management

Kidney injury has been associated with previous generations of GLP-1 medications, specifically exenatide and liraglutide

We conclude that despite data in support of anti-aging benefits, the evidence that metformin increases lifespan remains controversial

Results A total of 11 studies were included in this meta-analysis, including 6 studies on GLP-1 RA, 1 study on GLP-1 and GIP dual receptor agonists, 1 study on orlistat, 2 studies on phentermine-topiramate, and 1 study on naltrexone-bupropion (Additional file 1: Table S2) [22,23,24,25,26,27,28,29,30,31,32]