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While newly approved pharmacotherapies such as glucagon-like peptide-1 receptor agonists (GLP-1 RAs) show efficacy, their clinical utility remains constrained by dose-dependent gastrointestinal complications, underscoring the urgent need for safer alternatives

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Glucagon-like peptide-1 (GLP-1)is an incretin hormonealso classified as a gut-derived peptidesecreted by intestinal L-cells in response to nutrient ingestion, particularly carbohydrates and fats