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10.1007/s00125-022-05715-4 38 KarleI

Indeed, experiments which could provide indirect evidence for this hypothesis suggest that functional connectivity between the two systems may in fact be very limited 18,19 The difficulty in testing this link partly arises from the inherent complexity of interrogating these widely-distributed systems using pharmacological approaches, compounded by observations that native GLP-1 and pharmacokinetically-optimised therapeutic GLP-1 receptor agonists (GLP-1RAs) suppress eating via apparently divergent signalling pathways 1925

By 1989 the Copehnagen researchers had managed to complete the full sequence for porcine peptide and confirmed the sequence for the human peptide originally predicted by Bell in 1983

Liraglutide and sitagliptin have no effect on intestinal microbiota composition: a 12-week randomized placebo-controlled trial in adults with type 2 diabetes

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