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4 Receptor binding activates adenylate cyclase causing intracellular accumulation of cyclic adenosine monophosphate (cAMP), which activates protein kinase A (PKA) and triggers insulin secretion

& Sokolowski, C

Although EMPEROR-R enrolled patients with and without type 2 diabetes, the primary outcome of the trial (a composite of CV death and hospitalization for HF) was almost identical in both groups, suggesting that the different population didnt affect the results, at least for the primary outcome

Together, these data support a model in which GLP-1 signaling recalibrates mesocorticolimbic excitability and synaptic plasticity via convergent modulation of dopaminergic, glutamatergic, and GABAergic pathways

[DOI] [PubMed] [Google Scholar] Schrder-Tittmann K, Bosse-Doenecke E, Reedtz-Runge S, Ihling C, Sinz A, Tittmann K, Rudolph R

Exercise also provides cardiovascular and metabolic benefits that complement the effects of GLP-1 medications