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49 It is interesting that the double Aib substitutions led to comparable receptor binding and potency (IC 50 = 1.1 nM, EC 50 = 0.06 nM compared to GLP-1 (IC 50 = 1.5 nM, EC 50 = 0.08 nM)), whereas a single Aib at position 8 brought in a 4-fold decrease in potency and 2-fold increase in binding affinity

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10.1080/14656566.2024.2391524 10 BliddalH.BaysH.CzernichowS.Uddn HemmingssonJ.HjelmesthJ.Hoffmann MorvilleT.et al (2024)

doi: 10.3233/JPD-140364

Also, consternation of IL-8 level was significantly lower in CAD group 9)

That is why meals containing adequate protein often reduce snacking and late-night cravings
