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Description
57 (2), R93r108
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10.1016/S0140-6736(87)91194-9 74 LamontB
Dealing with practical issues: injections and gastrointestinal tolerability The main advantages of DPP-4 inhibitors compared with GLP-1RAs are less frequent nausea and oral administration
Mechanism In response to a previous FDA inquiry, two short-term mechanical studies were conducted using exenatide and liraglutide in a diabetic rat model, wherein one rat administered with exenatide died of pancreatic necrosis, while the others exhibited acinar-to-ductal metaplasia and ductal hyperplasia, indicative of potential premalignant alterations [62,63]
Intestinal microbiota and chronic constipation
