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With those types of numbers, its clear Amble is making a pretty big impact in the telehealth space, which means it deserves a place in my lineup of reviews

Conditions being studied Scientists are looking at how GLP1 agonists impact: Progression of diabetic retinopathy , a diabetes-related eye disease that can cause blurriness and blindness While initial studies indicated that diabetic retinopathy could worsen while taking this medication, more recent, large-scale data suggests that there is no increased risk

This posed a particular challenge to Novo Nordisks sales of its weight loss therapeutics, as did competition from Eli Lillys Zepbound, a glucose-dependent insulinotropic polypeptide and GLP-1 receptor, which performed better than Wegovy in terms of its ability to lower weight

The landmark phase 2 trial published in the New England Journal of Medicine used a structured escalation from 1mg through to 12mg per week across six separate dose arms, with participants achieving up to 24.2% body weight reduction at the highest escalation

Before and after comparisons at this stage show noticeable but not dramatic changes

383 In a phase 2 trial in adults without diabetes and BMI over 30 kg/m 2 , or 27 kg/m 2 plus comorbidities, cagrilintide was compared to liraglutide and placebo