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In the Phase 3 trials, adults taking retatrutide 12mg lost an average of 28.7% of their body weight after 68 weeks

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The slower transit time means more fermentation, more gas production, and more discomfort

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One thing is that, in trials, some of these new medications are increasing the amount of weight loss, but that means higher reward, higher risk, with more side effects, says John Morton, MD, MPH, chief of Yale Medicine Bariatric and Minimally Invasive Surgery and a board-certified obesity medicine specialist