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Gastrointestinal side effects from tirzepatidenausea, vomiting, constipation, or diarrheacould coincide with tamoxifen's own GI effects, potentially worsening tolerability

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4,25 Mechanisms of action of GLP-1RAs GLP-1 RAs are synthetically produced recombinant polypeptides designed to mimic the effects of natural GLP-1, but with a longer duration of action