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In animal models, this alcohol-induced reward is characterized by activation of the mesolimbic dopamine system, and it can be studied in preclinical models that involve hyperlocomotion, dopamine release in the NAc, and reward in the conditioned place preference (CPP) paradigm (Sanchis-Segura and Spanagel, 2006)

Vaporized cannabis resulted in higher blood THC concentrations than oral cannabis, but the difference did not reach statistical significance ( p 0.05)

doi: 10.1016/j.clinre.2016.12.007 29 MousaviTNikfarSAbdollahiM

Elevate and enhance training of the clinical trial workforce on state-of-the-art understanding of effective lifestyle interventions

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Conclusion: Long-term randomized placebo-controlled trials with larger sample sizes are needed to provide stronger evidence on the long-term efficacy and safety of semaglutide for obesity treatment in PWS as well as explore the potential synergistic effects of GLP-1 RA treatment combined with other therapeutic interventions