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If you feel persistently down, numb, or lose interest in life, bring it up quickly with your provider
Metformin is generally weight-neutral or causes slight weight loss
Acting on the cardiovascular system GLP-1 may have certain effects on the cardiovascular system, mainly manifested as increased heart rate and changes in blood pressure.Heart rate increase: The use of GLP-1 receptor agonists can cause an increase in heart rate in patients, and the magnitude of the increase in heart rate is related to the duration of GLP-1 action
Per the TrumpRx site, it is expected to launch in January 2026

Fatigue is a well-recognised factor that can reduce libido
doi: 10.1016/j.molmet.2021.101240 88 LudwigMQChengWGordianDLeeJPaulsenSJHansenSNet al
