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Beyond glucose and appetite, some agents in the class have demonstrated cardiovascular benefits in people with type 2 diabetes at high risk, such as reductions in major adverse cardiovascular events

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Figure 3 All these trials amount standard features: TZP is surveyed at three decisive doses (5, 10, and 15 mg per week)

Additional preclinical proof of concept came from similar studies in rodent models of T2D and/or obesity wherein the combined activation of both GLP-1R and GIPR resulted in superior glucose-lowering and/or reduction in weight gain compared to the activation of either receptor alone [[78], [79], [80]]

most (75%) were mild