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Users do not need to refrigerate the medication

The finding suggests that the effects of GLP-1s could be extended, potentially reducing how often these drugs must be administered

RV and KJ contributed to writing, reviewing and editing the manuscript, as well as validation and visualization

These findings are consistent with the in vitro results that GLP-1 induces AMPK phosphorylation, inhibits PARP-1, therefore increasing LXR-mediated ABCA1 expression

Published clinical trial data suggests retatrutide produces more pronounced metabolic effects than earlier-generation compounds in the populations studied