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This is a significant development because it is the first oral GLP-1 medication with an FDA-approved indication for weight management

frontiersin.org Fadel, L

Clinical and pharmaceutical applications may require higher concentrations for patient convenience or formulation requirements

Furthermore, in ECL1 of GCGR there are two glycine residues (G207 ECL1 , G219 ECL1 ) that disconnect the helical structure in the active state, whereas the G219 ECL1 is not conserved in GLP-1R and the helical conformation is relatively intact in this region of GLP-1R

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