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Description
Collectively, there is therefore a large body of mechanistic data to show that GLP-1 RAs exert pleiotropic actions on platelets and immune and vascular cells that would protect against the development and complications of atherosclerosis independently of, and in addition to, their canonical effects on glycaemia, appetite and weight regulation

An J, Zhou Y, Zhang M, Xie Y, Ke S, Liu L, et al
pmid:35675406 55

doi: 10.1111/dom.15185, PMID: [DOI] [PubMed] [Google Scholar] 18

While most major insurers and Medicare plans cover GLP-1s for T2D, coverage for GLP-1s for obesity and weight management is much more limited and often excluded from standard plans

Transdermal patches, by contrast, have not been evaluated in large human safety trials, so the incidence and severity of side effects remain unknown
