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In a Semaglutide Treatment Effect in People with Obesity (STEP) trial, semaglutide 2.4 mg plus lifestyle modification produced substantial, durable weight loss beyond lifestyle alone 13

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Most side effects diminish within 2-4 weeks as your body adjusts, though some patients require dose reduction or discontinuation

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The Food and Drug Administrations Adverse Event Reporting System (FAERS) has received at least 265 reports of suicidal thoughts or behavior in patients taking similar drugs since 2010, according to Reuters analysis

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