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Stopping suddenly after weeks on the medication can trigger rebound hunger and metabolic adjustment, while continuing during severe gastrointestinal illness might worsen nausea or mask important symptoms

Pancreatic Effects: In pancreatic -cells, semaglutide enhances glucose-stimulated insulin secretion by increasing intracellular cAMP levels and promoting calcium influx

Tolerability, ease of administration, minimal monitoring requirements and cost are also important determinants of acceptability, and preventive advantage for individuals with impaired glucose tolerance would be very desirable

Interestingly, the blood pressure reduction seems to be independent of disease status or presence of antihypertensive agents

Flatt PR (2008) Gastric inhibitory polypeptide (GIP) revisited: a new therapeutic target for obesity-diabetes

Others might keep losing hair until they stop the drug