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48 Exenatide Drugs and Lactation Database (2023)

doi: 10.1016/j.brainres.2019.146562 [DOI] [PubMed] [Google Scholar] 163.Bornebusch AB, Fink-Jensen A, Wrtwein G, et al

A sensitized high-throughput screen identified a series of small molecule GLP-1R agonists that were optimized to promote endogenous GLP-1R signaling with nM potency

Interestingly, both hMSC-Ex-4 and wild-type hMSC treated with soluble Ex-4 exhibited elevated mRNA expression of GLP-1-R in a dose-dependent manner, suggesting a feedback mechanism that may potentiate hMSC responsiveness to Ex-4 [18]

Other trials also reported a reduction in body weight, HbA1c, and FPG in patients receiving combination therapy with SGLT-2i plus GLP-1RA [9, 23, 46]

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