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Initially developed for diabetes management, these medications have demonstrated remarkable effectiveness for weight reduction, with clinical trials showing participants losing 15-20% of their total body weight on average results previously achievable only through bariatric surgery

The activation of PPAR- promotes insulin sensitization and has a role in lipid storage, whereas the activation of PPAR-/ enhances fatty acid metabolism and reveals anti-inflammatory effects by inhibiting inflammatory macrophage phenotypes

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But the research supporting these and other natural weight-loss alternatives is limited

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