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Ligand binding models provided logical explanations for SAR correlations

[49] Bupropion has several features that distinguish it from other antidepressants: for instance, unlike the majority of antidepressants, it does not usually cause sexual dysfunction, and the occurrence of sexual side effects is not different from placebo

Obesity 14 , 11241131 (2006)

Brand-name medication costs create significant barriers for many people

Research protocols that begin at the target dose without escalation may produce confounding adverse effect data

Lower costs could broaden treatment uptake but they will not eliminate access challenges without supportive coverage and affordability programs, especially for underserved populations