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The glucagon-like peptide-1 receptor (GLP-1R) is a class B G protein-coupled receptor and mainstay therapeutic target for the treatment of type 2 diabetes and obesity

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In recent years, many payers have taken steps to limit the costs of GLP-1s and introduced limits to coverage for the use of these products for weight loss.

Current brain-targeted delivery strategies using orthosteric sites of receptors is highly susceptible to cross-reactions limiting efficiency