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Ryder JR, Kaizer A, Rudser KD, Gross A, Kelly AS, Fox CK

Long-term opioid therapy often leads to reduced analgesic efficacy, requiring higher doses that increase the risk of dependency and adverse effects [79]

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Other reported side effects include injection site reactions (pain, redness, swelling), low potassium levels (hypokalemia), and potential heart failure when combined with thiazolidinediones
