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Tirzepatide, the active ingredient in Zepbound and Mounjaro, is part of new class of medications used to treat obesity and diabetes that have skyrocketed in popularity, driving shortages and leading some people to use versions made by compounding pharmacies

Factors to discuss Clinicians and patients should discuss benefits, harms, costs, weight-loss goals, access and availability, clinical comorbidities, life expectancy, values and preferences, and contraindications and warnings when initiating a recommended drug for weight loss or switching to another recommended treatment due to an inadequate response, Qaseem and colleagues wrote

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