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The FDA approval of Wegovy for certain adults with MASH and moderate-to-advanced fibrosis made this connection even more important for patients to understand

While some studies found no difference between individuals with T2DM and matched non-diabetic controls (6769), others found plasma DPP-4 activity to be reduced in the patients, and suggested this might reflect a compensatory response to the reduced insulin sensitivity and hyperglycaemia, in an attempt to increase intact incretin hormone concentrations and improve insulin secretion (70, 71)

This costly mistake affects countless manufacturers and researchers worldwide

Importantly, the narrative is balanced by acknowledging null findings, such as the study by Shirazi-Beechey et al