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Initially approved for treating type 2 diabetes, they have become a go-to therapy for adults who are obese or overweight

Our results indicate that these peptides modulate TRPV1 function via the extracellular membrane, effectively suppressing activation by CAP without impacting proton-related activation (Supplementary Fig

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Although all of the above-mentioned studies combined GLP-1 therapy with some form of lifestyle counselling, in each case the latter was described as standardised and infrequent, and can therefore be assumed to have been very much secondary to the medication

For people living with obesity, having a once-weekly treatment option that can deliver that level of outcome is a meaningful step forward

In contrast to most studies that assessed anticipatory reward responses, Han and colleagues (2018a) used a reinforcement schedule to induce reward-prediction errors while assessing reward learning