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A large proportion of participants achieved key weight-loss milestones (5% to 25%), and treatment was also associated with improvements in both general (SF-36v2) and obesity-specific (IWQOL-Lite-CT) quality of life

Renal impairment does not require dose adjustment according to the FDA label, though monitoring renal function is important, especially if severe gastrointestinal adverse effects occur, as these may lead to dehydration and acute kidney injury
These levels are associated with optimal outcomes for most individuals under provider care

This section discusses the clinical positioning of two high-value, cost-conscious strategies: orlistat pharmacotherapy and bariatric surgery

PRECAUTIONS General The safety and efficacy of oral levocarnitine has not been evaluated in patients with renal insufficiency
