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Main Text Glucagon-like peptide-1 (GLP-1), a neuroendocrine hormone, is derived from a proglucagon precursor ( 1 ) and secreted by intestinal enteroendocrine L cells in response to nutrient intake ( 2 ), predominantly in the form of GLP-1(7-36) amide (henceforth GLP-1) ( 3 )

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Genetic variants in GLP1R, GIPR, FTO, and MC4R genes influence how individuals respond to GLP-1 therapy at the cellular level

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Gastrointestinal losses can result in hypokalaemia, which may manifest as muscle weakness, cramps, cardiac arrhythmias, and constipation

Any persistent or severe skin reaction should prompt medical evaluation