is glp 1 produced in the body What GLP-1? Hormone Powering Weight Loss Medications – Revolution Health & Wellness Benefits of Semaglutide GLP-1 Injections

It's important to note that weight loss itself is an evidence-based therapy for GERD, so the weight reduction achieved with these medications may actually improve reflux symptoms in some patients, potentially offsetting any direct effects on the gastroesophageal junction

In most models of obesity, leptin concentrations are elevated, indicating the importance of leptin resistance in the pathogenesis of obesity

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J Neurosci2008 Jul 9;28(28):7202-8

Not sure if it was direct or indirect central modulation

However, as more people use the drug, the possibility of occurrence of rare adverse events also increases