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Ozempic is FDA approved and available now by prescription, while Retatrutide remains in Phase 3 trials with expected approval in late 2026 to early 2027

cAMP responses to exendin-4, with an intermediate pattern, were potentiated in arrestin-null cells, showing both increased potency and a trend toward higher efficacy over time compared to wild-type
Rev Latinoam Enferm 16:238244 Iglay K, Hannachi H, Joseph Howie P, Xu J, Li X, Engel SS, Rajpathak S (2016) Prevalence and co-prevalence of comorbidities among patients with type 2 diabetes mellitus

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