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Efficacy and safety of saxagliptin combination therapy in US patients with type 2 diabetes
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Nonetheless, GLP-1 medicines also exert anti-inflammatory effects independent of their metabolic effects
Institute of Medical Sciences, University of Toronto, Toronto, ON, M5 S1A8, Canada
Lancet Diabetes Endocrinol 6:605617 Mosenzon O, Blicher TM, Rosenlund S, Eriksson JW, Heller S, Hels OH et al (2019) Efficacy and safety of oral semaglutide in patients with type 2 diabetes and moderate renal impairment (PIONEER 5): a placebo-controlled, randomised, phase 3a trial
These findings suggest that GLP-1 medicines modulate inflammation through multiple pathways, including systemic metabolic improvements, direct actions on immune cells, and effects on non-immune cells that support interorgan communication of antiinflammatory signals (Figure 1 and Figure 2)
