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Final Thoughts Willow and Ro are both reputable sources for obtaining GLP-1 medications and ongoing support for eligible patients

The winners will be the assets that close it: either via oral formulations that improve adherence (ASC37, SP-2297, Rani), via long-interval dosing that reduces attrition (monthly ASC37 SC, Fc-fusion MWN-101/ZX2021), via better tolerability ratios (small-molecule HM-15275), or via combination formulations that add amylin or calcitonin effects on top of the triple agonist (AstraZeneca's combination-centric patent position is the early signal of this thesis)

Based on early data that show a high prevalence of CAI ( The literature data generally supports the evidence that individuals with PWS in common clinical practice do not typically experience adrenal insufficiency, are not usually treated with daily glucocorticoids, and do not generally experience adrenal crises during surgery or other stressful procedures and events

However, it is not uncommon for patients to notice weight loss within the first two months

see Supplement 5.5
