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This therapeutic effect has also been explored in patients with obesity and major depressive disorder, a population often affected by overlapping pathophysiological processes such as insulin resistance, inflammation, and altered reward system function [33,42,70]

Discontinuation: If symptoms are severe, persistent, or suggestive of hypersensitivity, discontinuing the medication may be necessary

Risk Factors That Increase Semaglutide Overdose Severity Patients with chronic kidney disease, dehydration, severe gastrointestinal disorders, or history of pancreatitis face heightened risk of serious complications from semaglutide overdose because their bodies cannot tolerate the fluid loss and metabolic stress as effectively

Adjust goals as needed

Systematic reviews and meta-analyses of randomised controlled trials suggest that berberine may modestly reduce fasting blood glucose, HbA1c (a marker of long-term glucose control), and post-meal glucose levels in people with type 2 diabetes or non-diabetic hyperglycaemia (prediabetes)