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Tirzepatide showed no significant difference regarding primary endpoints
Of all glucose-lowering therapies, only sodiumglucose cotransporter 2 inhibitors (SGLT2is) and glucagon-like peptide 1 receptor agonists (GLP-1 RAs) consistently result in weight improvement
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The results prompt safety concerns for GLP-1RAs, especially with high dose administration, regarding gastrointestinal adverse events
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