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Food travels through the stomach at a slower rate, further optimizing satiation, portion control, and total caloric consumption

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After 7 days, roughly half of a typical GLP-1 dose remains active

These effects may well be relevant for the cardiovascular benefits associated with GLP-1RA treatment and, as discussed, appear to be both dependent and independent of the effects on gastric emptying

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16, 17, 18, 19 Cells positive for GLP-1 mRNA are widely expressed in the human brain in areas, including the frontal, parietal, temporal and occipital cortices