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These substance-specific mechanisms, coupled with interindividual variability in GLP-1R distribution and gutbrain signaling capacity, highlight the need for precision-tailored rather than uniform treatment strategies

Naltrexone/bupropion (Contrave) Contrave is a combination of naltrexone and bupropion

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Future work surrounding oral biologic drug delivery is still necessary to increase oral bioavailability and allow other less potent drugs to be administered orally as well