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Oral semaglutide remains the only approved oral GLP-1 receptor agonist and showed this benefit in addition to standard-of-care therapies.The SOUL trial achieved its primary endpoint, with risk reductions across all MACE components: 26 per cent for nonfatal myocardial infarction, 12 per cent for nonfatal stroke, and 7 per cent for cardiovascular death

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Semaglutide mimics one hormone, and tirzepatide mimics two hormones, and a new medication called retatrutide is under review that mimics three different hormones