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Comparative efficacy of glucose-lowering drugs on liver steatosis as assessed by means of magnetic resonance imaging in patients with type 2 diabetes mellitus: systematic review and network meta-analysis

Safety and Side Effects GLP-1 receptor agonists are generally safe, with predictable side effects: Gastrointestinal symptoms such as nausea, vomiting, and diarrhea are common but usually improve with gradual dose titration

Semaglutide is more commonly associated with fatigue than insomnia, while tirzepatide user communities report a slightly higher incidence of sleep disruption

In prediabetes, metformin has evidence for delaying progression to type 2 diabetes in selected higher-risk groups, such as younger adults with higher body weight or people with a history of gestational diabetes

Across studies of adults with type 2 diabetes designed to measure A1C reduction, average body weight changes ranged from 7.1 lb to 14.1 lb, though some participants gained weight

Patient B: Jennifer, 43 Starting weight: 242 pounds Height: 57 Exercise approach: No resistance training, some walking, protein intake around 50-60g daily After 11 months: Weight: 168 pounds (74 pounds lost) Body fat: 34% (down from 43%) DEXA scan: 47 pounds fat lost, 27 pounds muscle lost Resting metabolic rate: Dropped 280 calories from baseline Clothing size: 22 to 12 Strength: Not assessed (no baseline) Jennifer looked deflated